Area of research
Surgery · Molecular Biology
Research interest
Research interests include Pancreatic function and diabetes, Diabetes and associated disorders, Epigenetics and DNA Methylation, and FOXO transcription factor regulation.
Epigenetic adaptation of beta cells across lifespan and disease
G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells
The house mouse maintains constant telomere length throughout life
DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets
Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling
FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes
Cancer stem cells: advances in biology and clinical translation—a Keystone Symposia report
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
The Dynamic Chromatin Architecture of the Regenerating Liver
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer
Comparative analysis of commercially available single-cell RNA sequencing platforms for their performance in complex human tissues
A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice
The dynamic chromatin architecture of the regenerating liver
A high-content <i>in vivo</i> screen to identify microRNA epistasis in the repopulating mouse liver
Epigenetics and Epigenomics: Implications for Diabetes and Obesity
Molecular Genetic Analysis of the Role of Senescence in Liver Disease
Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D)
Beta cell death in early type 1 diabetes caused by innate immune response to inefficient RNA editing
Utility of Random Biopsies in Inflammatory Bowel Disease
Utility of Random Biopsies in Inflammatory Bowel Disease
FOXL1 positive telocytes in intestinal development and homeostsis
FOXL1 positive telocytes in intestinal development and homeostsis
FOXL1 positive telocytes in intestinal development and homeostsis
The role of senescent beta cells in T1D and T2D
The role of senescent beta cells in T1D and T2D
The role of senescent beta cells in T1D and T2D
The role of senescent beta cells in T1D and T2D
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression
Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression
Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression
Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression
Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression
Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D)
The Human Pancreas Analysis Program for Type 2 Diabetes