Area of research
Surgery · Genetics
Research interest
Research interests include Biology, Internal medicine, Chromatin, Transcriptome, Endocrinology, and Beta cell.
Epigenetic adaptation of beta cells across lifespan and disease
G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
Latent plasticity of the human pancreas across development, health, and disease
CelFiE-ISH: a probabilistic model for multi-cell type deconvolution from single-molecule DNA methylation haplotypes
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets
Characterization of metabolic alterations in the lean metabolically unhealthy alpha defensin transgenic mice
Author Correction: CelFiE-ISH: a probabilistic model for multi-cell type deconvolution from single-molecule DNA methylation haplotypes
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes
Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
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