Area of research
Genetics · Endocrinology, Diabetes and Metabolism
Research interest
Biography Dr. José Ordovás, PhD, is a Senior Scientist and leader of the Precision Nutrition & Healthy Aging directive at the HNRCA. He is a globally recognized pioneer in the fields of nutrigenomics and precision nutrition. Dr. Ordovás's research explores how genetic and epigenetic variation influence individual responses to diet, with a strong emphasis on cardiometabolic health, obesity, and aging. He has been instrumental in defining the scientific basis for gene-diet interactions and their translation into precision strategies for chronic disease prevention. His group integrates state-of-the-art omics tools -- genomics, epigenomics, metabolomics, and microbiome profiling -- with AI-driven analytics and clinical phenotyping. Dr. Ordovás has led or contributed to numerous international studies and consortia and serves in key advisory roles, including chairing the Functional Genomics Core Scientific Advisory Committee at Tufts University. He has published more than 960 peer-reviewed articles and several influential books, establishing him as one of the most cited scientists in his field. His recent work includes research on the APOA2 gene and dietary fat interaction, gut microbiota, inflammation, and the role of the TCF7L2 gene in the dietary prevention of type 2 diabetes. He is also a leading voice in emerging efforts to create AI-driven digital twins for personalized aging strategies and is actively involved in shaping national and international research agendas on planetary health, food systems resilience, and ultra-processed foods. Dr. Ordovás holds professorships in Nutrition and Genetics at the Friedman School of Nutrition Science and Policy and the Graduate School of Biomedical Sciences at Tufts University. He is a member of the Spanish Royal Academy of Pharmacy, the Academia Europaea, the American Society of Nutrition and an honorary member of the Latin American Society of Nutrition. Dr. Ordovás's scientific excellence has been recognized with numerous awar
Personalized nutrition: perspectives on challenges, opportunities, and guiding principles for data use and fusion
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs
The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels
Research gaps and opportunities in precision nutrition: an NIH workshop report
Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study
Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming mice via Nrf2/Keap1 signal pathway
Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis
Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition
A metabolomic signature of the APOE2 allele
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants
Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based?
Human postprandial responses to food and potential for precision nutrition
Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations
Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A
Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics
A gene-diet interaction-based score predicts response to dietary fat in the Women’s Health Initiative
Salivary AMY1 Copy Number Variation Modifies Age-Related Type 2 Diabetes Risk
Consumption of Ultra-Processed Foods and Mortality: A National Prospective Cohort in Spain
Perspective: Dietary Biomarkers of Intake and Exposure—Exploration with Omics Approaches
Ultra-processed Food Consumption and Incident Frailty: A Prospective Cohort Study of Older Adults
Lipidomic profiling identifies signatures of metabolic risk
DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos
Personalised nutrition and health
Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium