Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Enzyme Structure and Function, Protein Structure and Dynamics, RNA and protein synthesis mechanisms, and Advanced Electron Microscopy Techniques and Applications.
Categorizing prediction modes within low-pLDDT regions of
<i>AlphaFold</i>
2 structures: near-predictive, pseudostructure and barbed wire
Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures
RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge.
The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions
CERES: a cryo-EM re-refinement system for continuous improvement of deposited models.
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>
New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink “waters,” and NGL Viewer to recapture online 3D graphics
CaBLAM for chiropraxis in cryoEM, UnDowser to rethink “waters”, and NGL Viewer to recapture online 3D graphics in MolProbity validation
MolProbity: More and better reference data for improved all‐atom structure validation