Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Enzyme Structure and Function, Protein Structure and Dynamics, Protein purification and stability, and RNA and protein synthesis mechanisms.
New targets and procedures for validating the valence geometry of nucleic acid structures
Categorizing prediction modes within low-pLDDT regions of
<i>AlphaFold</i>
2 structures: near-predictive, pseudostructure and barbed wire
<i>Cis</i>
‐
<scp>nonProline</scp>
peptides: Genuine occurrences and their functional roles
Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures
RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge.
Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality
Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
AlphaFold predictions are valuable hypotheses, and accelerate but do not replace experimental structure determination
Accelerating crystal structure determination with iterative AlphaFold prediction
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge
Making the invisible enemy visible
The importance of residue‐level filtering and the Top2018 best‐parts dataset of high‐quality protein residues
The importance of residue-level filtering, and the Top2018 best-parts dataset of high-quality protein residues
Making the invisible enemy visible
Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>
New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink “waters,” and NGL Viewer to recapture online 3D graphics
CaBLAM for chiropraxis in cryoEM, UnDowser to rethink “waters”, and NGL Viewer to recapture online 3D graphics in MolProbity validation
MolProbity: More and better reference data for improved all‐atom structure validation
mcaGUI: microbial community analysis R-Graphical User Interface (GUI)
FMRG: Cyber: Manufacturing USA: Robotic Additive Manufacturing of Volumetrically-Oriented Multi-Functional Composites via Digital Twin-Informed Optimization
REU Site: CO2 Chemical Engineering: Opportunities and Challenges
I-Corps: Multi-axis Additive Manufacturing Process for Performance-Optimized Composites
CPS: TTP Option: Medium: Collaborative Research: Cyber-Physical System Integrity and Security with Impedance Signatures
I-Corps: High-temperature 3D Printer for High-Performance Polymers
GOALI: Additive Manufacturing of High Performance Elastomers via Vat Photopolymerization of Aqueous Polymer Dispersions
UNS: Selective Catalytic Conversion of Syngas-Derived Dimethyl Oxalate to Ethylene Glycol: Mechanistic Insights from In-Situ Surface Vibrational Spectroscopy
GOALI/Collaborative Research: Topology Optimization for Additively Manufactured Metal Castings
EAGER/Collaborative Research/Cybermanufacturing: Just Make It: Integrating Cybermanufacturing into Design Studios to Enable Innovation
Collaborative Research/Workshop: Educational Needs and Opportunities in Additive Manufacturing; Arlington, Virginia; April 10-11, 2014
CAREER: Additive Manufacture of Copper Cellular Materials
RET Site: Innovation-based Manufacturing
Collaborative Research: Electrochemical Reduction of CO2 to Small Organic Fuels on Encapsulated Metal Catalysts in Gas Diffusion Electrode Environment
REU SITE: Sustainable Energy in Chemical Engineering
Carbon Dioxide and Water Flux Responses to Extreme Weather and Climate Anomalies: A Fluxnet Synthesis
Carbon Dioxide and Water Flux Responses to Extreme Weather and Climate Anomalies: A Fluxnet Synthesis
Operando Vibrational Spectroscopic Investigation of Heterogeneous Asymmetric Hydrogenation on Transition Metal Catalysts
CAREER: Investigation of Catalysis at Solid-Liquid Interfaces by Non-Linear Optical Spectroscopy