Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Enzyme Structure and Function, Protein Structure and Dynamics, RNA and protein synthesis mechanisms, and Glycosylation and Glycoproteins Research.
New targets and procedures for validating the valence geometry of nucleic acid structures
Categorizing prediction modes within low-pLDDT regions of
<i>AlphaFold</i>
2 structures: near-predictive, pseudostructure and barbed wire
<i>Cis</i>
‐
<scp>nonProline</scp>
peptides: Genuine occurrences and their functional roles
Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures
RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.
Community recommendations on cryoEM data archiving and validation
Community recommendations on cryoEM data archiving and validation.
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge.
Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
Accelerating crystal structure determination with iterative AlphaFold prediction.
The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions
Improved AlphaFold modeling with implicit experimental information.
Improved AlphaFold modeling with implicit experimental information
AlphaFold predictions are valuable hypotheses, and accelerate but do not replace experimental structure determination
Accelerating crystal structure determination with iterative AlphaFold prediction
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge.
Making the invisible enemy visible
Improving SARS-CoV-2 structures: Peer review by early coordinate release
The importance of residue‐level filtering and the Top2018 best‐parts dataset of high‐quality protein residues
The importance of residue-level filtering, and the Top2018 best-parts dataset of high-quality protein residues
Improved chemistry restraints for crystallographic refinement by integrating the Amber force field into Phenix.
Making the invisible enemy visible
Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>
New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink “waters,” and NGL Viewer to recapture online 3D graphics
CaBLAM for chiropraxis in cryoEM, UnDowser to rethink “waters”, and NGL Viewer to recapture online 3D graphics in MolProbity validation