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Owain W. Howell

Swansea University · GB
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Area of research
Pathology and Forensic Medicine · Neurology
Research interest
Research interests include Multiple sclerosis, Pathology, Medicine, Inflammation, Microglia, and Grey matter.
h-index
citations
2,766
works
48
NIH funding
primary concept
email

Recent publications

Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis
Neurology Neuroimmunology & Neuroinflammation 2025cited by 5position: middledoi
Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics
Annals of Neurology 2025cited by 4position: middledoi
Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis
Brain Pathology 2025cited by 2position: lastdoi
Spatial transcriptomics of compartmentalised inflammation in a natural disease multiple sclerosis cohort
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 0position: middledoi
Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
Annals of Neurology 2024cited by 80position: middledoi
Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis
Brain Pathology 2024cited by 19position: middledoi
Digital Pathology Identifies Associations between Tissue Inflammatory Biomarkers and Multiple Sclerosis Outcomes
Cells 2024cited by 1position: lastdoi
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Nature Communications 2023cited by 170position: middledoi
Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis
Nature Reviews Neurology 2023cited by 81position: middledoi
Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis
Annals of Neurology 2023cited by 31position: lastdoi
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis
Frontiers in Cellular Neuroscience 2023cited by 18position: lastdoi
High Levels of Perivascular Inflammation and Active Demyelinating Lesions at Time of Death Associated with Rapidly Progressive Multiple Sclerosis Disease Course: A Retrospective Postmortem Cohort Study
Annals of Neurology 2023cited by 14position: middledoi
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development
iScience 2023cited by 8position: middledoi
“Ependymal‐in” Gradient of Thalamic Damage in Progressive Multiple Sclerosis
Annals of Neurology 2022cited by 65position: middledoi
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome
Brain Pathology 2022cited by 30position: lastdoi
A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
Biomedicines 2022cited by 26position: middledoi
A multicentre, open label, single-arm, phase 3b study (CONSONANCE) to assess the effectiveness and safety of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year-1 interim analysis (P1-1.Virtual)
Neurology 2022cited by 5position: middledoi
A multicenter, open label, single-arm, phase 3b study (CONSONANCE) to assess efficacy of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year 1 interim analysis of cognition outcomes (P1-1.Virtual)
Neurology 2022cited by 3position: middledoi
Analysis of target mRNAs in the fixed-frozen human brain using a modified BaseScope-ISH Assay protocol
STAR Protocols 2022cited by 1position: middledoi
Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging
Analytical Chemistry 2021cited by 68position: middledoi
Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis
Journal of Lipid Research 2021cited by 29position: middledoi
B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis
Brain Pathology 2020cited by 125position: middledoi
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
Proceedings of the National Academy of Sciences 2020cited by 87position: middledoi
Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier
PLoS Biology 2020cited by 58position: middledoi
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans
Cell Reports Medicine 2020cited by 37position: middledoi
Substantial subpial cortical demyelination in progressive multiple sclerosis: have we underestimated the extent of cortical pathology?
Neuroimmunology and Neuroinflammation 2020cited by 16position: lastdoi
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis
Journal of Neuroinflammation 2020cited by 15position: middledoi
Neuroinflammation in the normal appearing white matter of multiple sclerosis brain causes abnormalities at the node of Ranvier
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 4position: middledoi
Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 1position: middledoi
Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis
Journal of Neuroinflammation 2019cited by 134position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Richard Reynolds · Imperial College London21 papers (2012–2024)Roberta Magliozzi · University of Verona15 papers (2012–2025)Richard Nicholas · Imperial College Healthcare NHS Trust12 papers (2012–2025)James Neal · Swansea University11 papers (2014–2024)Lauren Griffiths · Swansea University9 papers (2018–2025)Neil P. Robertson · Swansea University8 papers (2014–2025)Eylan Yutuc · Swansea University7 papers (2018–2025)Lewis M. Watkins · Swansea University7 papers (2014–2024)William J. Griffiths · Swansea University7 papers (2018–2025)B. Paul Morgan · Neurological Surgery7 papers (2014–2023)Sam Loveless · Cardiff University6 papers (2014–2020)Yuqin Wang · Shandong University6 papers (2018–2023)Benjamin Cooze · Swansea University5 papers (2020–2024)Roberto Angelini · Swansea University5 papers (2018–2025)Mark I. Rees · Swansea University5 papers (2014–2023)Federico Roncaroli · Imperial College Healthcare NHS Trust5 papers (2012–2023)Massimiliano Calabrese · University of Padua5 papers (2018–2025)Rhian Evans · Swansea University5 papers (2017–2023)Denise Fitzgerald · Queen's University Belfast5 papers (2018–2025)Michelle Naughton · Queen's University Belfast5 papers (2018–2025)
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