Area of research
Hematology · Molecular Biology
Research interest
Research interests include Acute Myeloid Leukemia Research, Chronic Myeloid Leukemia Treatments, Protein Degradation and Inhibitors, and Cardiac Arrhythmias and Treatments.
Age-Related Ventricular Tachycardia Substrate Characteristics for Repaired Tetralogy of Fallot Before Transcatheter Pulmonary Valve Placement
<i>In Vivo</i> and <i>In Vitro</i> Chemical Synthetic Lethality of ABHD17 and MEK Inhibition in <i>NRAS</i>-Mutant Acute Myeloid Leukemia
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus
Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study
Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
Clinical Experience With the Subcutaneous Implantable Cardioverter–Defibrillator in Adults With Congenital Heart Disease
Catheter ablation of supraventricular tachyarrhythmia after extracardiac Fontan surgery
KRAS Engages AGO2 to Enhance Cellular Transformation
Somatic and Germline <i>TP53</i> Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Preclinical efficacy of MEK inhibition in Nras-mutant AML
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia
Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
Phase II Study of the Oral MEK Inhibitor Selumetinib in Advanced Acute Myelogenous Leukemia: A University of Chicago Phase II Consortium Trial
Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in <i>Nras-</i> Driven Hematopoietic Transformation