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Kevin Shannon

City College of San Francisco · US
Area of research
Hematology · Molecular Biology
Research interest
Research interests include Acute Myeloid Leukemia Research, Chronic Myeloid Leukemia Treatments, Protein Degradation and Inhibitors, and Cardiac Arrhythmias and Treatments.
h-index
73
citations
20,105
works
549
NIH funding
primary concept
email

Recent publications

Age-Related Ventricular Tachycardia Substrate Characteristics for Repaired Tetralogy of Fallot Before Transcatheter Pulmonary Valve Placement
JACC. Clinical electrophysiology 2025cited by 11position: middledoi
<i>In Vivo</i> and <i>In Vitro</i> Chemical Synthetic Lethality of ABHD17 and MEK Inhibition in <i>NRAS</i>-Mutant Acute Myeloid Leukemia
Blood 2024cited by 2position: lastdoi
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
Nature 2022cited by 217position: middledoi
MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus
Neuro-Oncology 2022cited by 96position: middledoi
Conduction System Pacing Versus Conventional Cardiac Resynchronization Therapy in Congenital Heart Disease
JACC. Clinical electrophysiology 2022cited by 47position: middledoi
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
Nature Chemical Biology 2021cited by 139position: middledoi
Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study
Heart Rhythm 2020cited by 68position: middledoi
Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome
JACC. Clinical electrophysiology 2020cited by 41position: middledoi
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice
Blood 2020cited by 40position: lastdoi
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice
JCI Insight 2020cited by 32position: lastdoi
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
Journal of Clinical Investigation 2019cited by 52position: middledoi
Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1
Journal of Clinical Oncology 2019cited by 47position: middledoi
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
Cell stem cell 2018cited by 305position: middledoi
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
Cancer Cell 2018cited by 109position: middledoi
Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy
PLoS ONE 2018cited by 17position: middledoi
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
Cell 2017cited by 184position: lastdoi
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
Nature Medicine 2017cited by 119position: middledoi
Clinical Experience With the Subcutaneous Implantable Cardioverter–Defibrillator in Adults With Congenital Heart Disease
Circulation Arrhythmia and Electrophysiology 2016cited by 80position: middledoi
Catheter ablation of supraventricular tachyarrhythmia after extracardiac Fontan surgery
Heart Rhythm 2016cited by 59position: middledoi
KRAS Engages AGO2 to Enhance Cellular Transformation
Cell Reports 2016cited by 45position: middledoi
Somatic and Germline <i>TP53</i> Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors
Clinical Cancer Research 2016cited by 35position: middledoi
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis
Nature Genetics 2015cited by 42position: middledoi
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Cancer Cell 2014cited by 320position: middledoi
Preclinical efficacy of MEK inhibition in Nras-mutant AML
Blood 2014cited by 104position: middledoi
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia
Nature 2014cited by 70position: lastdoi
Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy
Journal of the American College of Cardiology 2013cited by 286position: middledoi
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Blood 2013cited by 161position: middledoi
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
Nature 2013cited by 131position: middledoi
Phase II Study of the Oral MEK Inhibitor Selumetinib in Advanced Acute Myelogenous Leukemia: A University of Chicago Phase II Consortium Trial
Clinical Cancer Research 2013cited by 111position: middledoi
Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in <i>Nras-</i> Driven Hematopoietic Transformation
Cancer Discovery 2013cited by 68position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Scott C. Kogan · University of California, San Francisco6 papers (2012–2020)Ari J. Firestone · Enzo Life Sciences (United States)6 papers (2013–2021)Qing Li · Memorial Sloan Kettering Cancer Center6 papers (2013–2017)Benjamin J. Huang · University of California, San Francisco5 papers (2017–2024)Jeremy P. Moore · University of California, Los Angeles4 papers (2016–2022)Jin Xu · Hebei Agricultural University4 papers (2012–2014)Benjamin S. Braun · Boston University3 papers (2012–2020)Scott W. Lowe · Memorial Sloan Kettering Cancer Center3 papers (2014–2015)Anica M. Wandler · Seattle Children's Hospital3 papers (2017–2019)Kevin M. Haigis · Brigham and Women's Hospital3 papers (2013–2020)Benjamin F. Cravatt · Scripps Research Institute3 papers (2020–2024)Deepak Sampath · Amgen (United States)3 papers (2014–2017)Michael R. Burgess · Bristol-Myers Squibb (United States)3 papers (2014–2017)Michelle M. Le Beau · Cancer Prevention and Research Institute of Texas3 papers (2013–2017)Johannes Zuber · Research Institute of Molecular Pathology3 papers (2014–2015)Shann-Ching Chen · St. Jude Children's Research Hospital3 papers (2013–2014)Anagha Inguva Sheth · University of Colorado Denver2 papers (2018–2020)Joy Nakitandwe · Cleveland Clinic2 papers (2013–2014)Marina Predovic · Ames Research Center2 papers (2020–2021)Megan E. McNerney · University of Chicago2 papers (2013–2015)