Area of research
Neurology · Physiology
Research interest
Research interests include Frontotemporal dementia, Biology, Cell biology, Medicine, C9orf72, and Amyotrophic lateral sclerosis.
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture
Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia
The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding