Area of research
Cancer Research · Oncology
Research interest
Research interests include Biology, Warburg effect, Glycolysis, KRAS, Cancer, and Lactate dehydrogenase A.
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
Identifying transcriptional programs underlying cancer drug response with TraCe-seq
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells