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Robert Lafyatis

La Roche College · US
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Area of research
Pathology and Forensic Medicine · Molecular Biology
Research interest
Research interests include Systemic Sclerosis and Related Diseases, Connective Tissue Growth Factor Research, Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis, and Inflammatory Myopathies and Dermatomyositis.
h-index
83
citations
26,867
works
452
NIH funding
primary concept
Medicine
email

Recent publications

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
Science 2025cited by 40position: middledoi
An international perspective on the future of systemic sclerosis research
Nature Reviews Rheumatology 2025cited by 22position: middledoi
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
Nature Communications 2024cited by 73position: middledoi
An integrated cell atlas of the lung in health and disease
Nature Medicine 2023cited by 732position: middledoi
Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension
European Respiratory Journal 2023cited by 19position: middledoi
GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension
Scientific Reports 2023cited by 18position: middledoi
Abstract 17218: CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension
Circulation 2023cited by 1position: middledoi
Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis
Annals of the Rheumatic Diseases 2022cited by 39position: lastdoi
Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity
CHEST Journal 2022cited by 25position: middledoi
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung
Circulation 2021cited by 450position: middledoi
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
Nature Communications 2021cited by 353position: middledoi
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report
Transplantation and Cellular Therapy 2021cited by 143position: middledoi
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Journal of Clinical Investigation 2021cited by 74position: middledoi
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
Nature Communications 2021cited by 43position: middledoi
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell 2020cited by 2,483position: middledoi
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
Immunity 2020cited by 673position: middledoi
Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo‐Controlled Trial in Adults With Systemic Sclerosis
Arthritis & Rheumatology 2020cited by 102position: middledoi
Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial
The Lancet Rheumatology 2020cited by 45position: middledoi
Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
European Respiratory Journal 2019cited by 813position: lastdoi
Shared and distinct mechanisms of fibrosis
Nature Reviews Rheumatology 2019cited by 630position: lastdoi
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Nature Immunology 2019cited by 528position: middledoi
Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
Annals of the Rheumatic Diseases 2019cited by 357position: lastdoi
Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ
Immunity 2019cited by 346position: middledoi
Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase <scp>II</scp> Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial
Arthritis & Rheumatology 2019cited by 222position: middledoi
A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies
Nature Communications 2019cited by 86position: middledoi
Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial.
PubMed 2019cited by 38position: last
A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers
Arthritis Research & Therapy 2019cited by 30position: middledoi
OP0068 ABATACEPT IN EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS— RESULTS OF A PHASE 2 INVESTIGATOR-INITIATED, MULTICENTER, DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL
Annals of the Rheumatic Diseases 2019cited by 3position: middledoi
Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin
Frontiers in Immunology 2018cited by 88position: lastdoi
Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis
Arthritis & Rheumatology 2018cited by 63position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Giuseppina Stifano · Bristol-Myers Squibb (United States)12 papers (2013–2019)Robert W. Simms · Boston University11 papers (2013–2020)Michael L. Whitfield · Dartmouth College11 papers (2012–2020)Romy Christmann · AbbVie (United States)10 papers (2012–2017)Tracy Tabib · University of Pittsburgh10 papers (2017–2021)Lisa Rice · Moderna Therapeutics (United States)9 papers (2014–2022)Jessica Gordon · Hospital for Special Surgery7 papers (2015–2020)Wei Chen · Hebei Medical University7 papers (2017–2020)John Varga · Northwestern University7 papers (2012–2024)Cristina M. Padilla · University of Arizona6 papers (2012–2015)Dario A.A. Vignali · University of Pittsburgh6 papers (2018–2021)Jessica Ziemek · University of Washington6 papers (2015–2019)Allison L. Mathes · Boston University5 papers (2013–2015)Tullia C. Bruno · University of Pittsburgh5 papers (2018–2021)Giuseppina Farina · Boston University5 papers (2012–2015)Julio Mantero · Broad Institute5 papers (2016–2022)Dinesh Khanna · University of Michigan5 papers (2016–2024)Tammara Wood · Dartmouth College5 papers (2013–2020)Maria Trojanowska · Boston University5 papers (2012–2023)Robert Spiera · Hospital for Special Surgery5 papers (2015–2020)
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