Area of research
Infectious Diseases · Animal Science and Zoology
Research interest
Research interests include Virology, Biology, Coronavirus disease 2019 (COVID-19), Antibody, Coronavirus, and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
A coronavirus assembly inhibitor that targets the viral membrane protein
Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations
Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein
Sialoglycan binding triggers spike opening in a human coronavirus
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus