Area of research
Immunology and Allergy · Hematology
Research interest
Early studies from the Ginsberg laboratory established that the matrix protein fibronectin binds to specific cell surface receptors. These receptors are members of a widely distributed protein family, now termed integrins. This protein family is essential for the normal development and functioning of both vertebrates and invertebrates.
Regulated RIAM–Talin Engagement Controls Adhesion Stability and Mechanical Output
A CD25–chemokine receptor complex initiates noncanonical IL-2 signaling
Silencing
<i>KRIT1</i>
Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome
Transcriptomic signatures of individual cell types in cerebral cavernous malformation
Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy
IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations.
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease
Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
Cerebral Cavernous Malformation: From Mechanism to Therapy
Cerebral Cavernous Malformation: From Mechanism to Therapy.
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function.
Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling.
Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations
Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations.
Endothelial struts enable the generation of large lumenized blood vessels de novo.
Non cell-autonomous effect of astrocytes on cerebral cavernous malformations
Author response: Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations
Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid Organs
Talin-1 is the principal platelet Rap1 effector of integrin activation
Talin-1 is the principal platelet Rap1 effector of integrin activation
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
MARCH Proteins Mediate Responses to Antitumor Antibodies.
Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes