Area of research
Molecular Biology · Hematology
Research interest
Research interests include Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, Protein Degradation and Inhibitors, and Histone Deacetylase Inhibitors Research.
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells
Recruitment of FBXO22 for targeted degradation of NSD2
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias
SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
Recruitment of FBXO22 for Targeted Degradation of NSD2
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
Low muscle mass is associated with a higher risk of all–cause and cardiovascular disease–specific mortality in cancer survivors
HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
A Mutation in Histone H2B Represents a New Class of Oncogenic Driver
Decitabine limits escape from MEK inhibition in uveal melanoma
CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation
Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity
WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck
Abstract 2344: 3D extracellular stiffness cues drive localized changes in gene expression
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
A physical sciences network characterization of non-tumorigenic and metastatic cells
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies