Roman L. Bogorad

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration

Identification of a long non-coding RNA regulator of liver carcinoma cell survival

Liquid-crystal organization of liver tissue

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

Treatment of erythropoietin deficiency in mice with systemically administered siRNA