Area of research
Immunology and Allergy · Molecular Biology
Research interest
Research focused on Cell biology and Gene silencing, with related work in Genome editing, Uniporter, In vivo. Notable publications include 'Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo', 'Origins of tumor-associated macrophages and neutrophils', and 'In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight'.
Identification of a long non-coding RNA regulator of liver carcinoma cell survival
Liquid-crystal organization of liver tissue
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
Silencing of CCR2 in myocarditis
Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice
Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice
Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter
MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling
Origins of tumor-associated macrophages and neutrophils
Rab5 is necessary for the biogenesis of the endolysosomal system in vivo
Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
Treatment of erythropoietin deficiency in mice with systemically administered siRNA