Area of research
Immunology · Oncology
Research interest
Research interests include T-cell and B-cell Immunology, Immune Cell Function and Interaction, CAR-T cell therapy research, and Immunotherapy and Immune Responses.
A metabolic atlas of mouse aging
Tumour priming by ultrasound mechanogenetics for CAR T therapy
Xist ribonucleoproteins promote female sex-biased autoimmunity
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
Engineered cell entry links receptor biology with single-cell genomics
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits
The cis-Regulatory Atlas of the Mouse Immune System
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation
Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection