Area of research
Immunology · Cancer Research
Research interest
Research interests include Immune Cell Function and Interaction, Cancer Genomics and Diagnostics, CRISPR and Genetic Engineering, and T-cell and B-cell Immunology.
Enhancer activation from transposable elements in extrachromosomal DNA
Genetic elements promote retention of extrachromosomal DNA in cancer cells
Bidirectional epigenetic editing reveals hierarchies in gene regulation
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer
Divergent clonal differentiation trajectories of T cell exhaustion
The evolutionary dynamics of extrachromosomal DNA in human cancers
Engineered cell entry links receptor biology with single-cell genomics
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
ecDNA hubs drive cooperative intermolecular oncogene expression
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance
Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation
Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions
Abstract C24: Interplay between ECM stiffness, miR-203 and mammographic density
Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration
Rapid disorganization of mechanically interacting systems of mammary acini