Area of research
Immunology · Oncology
Research interest
Research interests include Immune Cell Function and Interaction, T-cell and B-cell Immunology, CAR-T cell therapy research, and Immunotherapy and Immune Responses.
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
Unified molecular approach for spatial epigenome, transcriptome, and cell lineages
Genetic elements promote retention of extrachromosomal DNA in cancer cells
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
17 Optimized Workflow for Unbiased Massively Parallel Single Cell Profiling in Human Brain Samples from Autopsy
Xist ribonucleoproteins promote female sex-biased autoimmunity
Coordinated inheritance of extrachromosomal DNAs in cancer cells
Bidirectional epigenetic editing reveals hierarchies in gene regulation
Disparate Pathways for Extrachromosomal DNA Biogenesis and Genomic DNA Repair
Clonal inactivation of TERT impairs stem cell competition
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
Clonal hematopoiesis is associated with protection from Alzheimer’s disease
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
Coordinated inheritance of extrachromosomal DNA species in human cancer cells
Engineering circular RNA for enhanced protein production
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer
Divergent clonal differentiation trajectories of T cell exhaustion
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
Enhanced T cell effector activity by targeting the Mediator kinase module
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Engineered cell entry links receptor biology with single-cell genomics
Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state
Author Correction: Engineering circular RNA for enhanced protein production
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
ecDNA hubs drive cooperative intermolecular oncogene expression
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance