Area of research
Molecular Biology · Genetics
Research interest
Research interests include RNA and protein synthesis mechanisms, CRISPR and Genetic Engineering, RNA modifications and cancer, and RNA Research and Splicing.
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates
Cell-free biosensors for rapid detection of water contaminants
De novo-designed translation-repressing riboregulators for multi-input cellular logic
A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control
Computational design of three-dimensional RNA structure and function
PLANT-Dx: A Molecular Diagnostic for Point-of-Use Detection of Plant Pathogens
Distinct timescales of RNA regulators enable the construction of a genetic pulse generator
High-throughput determination of RNA structures
Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression
Computational design of small transcription activating RNAs for versatile and dynamic gene regulation
Cotranscriptional folding of a riboswitch at nucleotide resolution
Characterizing RNA structures in vitro and in vivo with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
Creating small transcription activating RNAs
A renaissance in RNA synthetic biology: new mechanisms, applications and tools for the future
Characterizing and prototyping genetic networks with cell-free transcription–translation reactions
Simultaneous characterization of cellular RNA structure and function with in-cell SHAPE-Seq
Generating Effective Models and Parameters for RNA Genetic Circuits
Rapidly Characterizing the Fast Dynamics of RNA Genetic Circuitry with Cell-Free Transcription–Translation (TX-TL) Systems
SHAPE-Seq 2.0: systematic optimization and extension of high-throughput chemical probing of RNA secondary structure with next generation sequencing
The centrality of RNA for engineering gene expression
A modular strategy for engineering orthogonal chimeric RNA transcription regulators
An RNA Mapping DataBase for curating RNA structure mapping experiments
SHAPE–Seq: High‐Throughput RNA Structure Analysis
URoL:ASC: The design, development, and societal impact of rapid, in-home, water quality biosensors
Transitions: Evolving our Understanding of Dynamic RNA Folding and Function
RAPID: Point-of-Need Detection of COVID-19 using CRISPR-Enabled Cell-Free Synthetic Biology
Collaborative Research: Uncovering How Riboswitches Exploit Out-of-Equilibrium RNA Folding Pathways to Make Genetic Decisions
RAPID: Collaborative Research: A cell-free synthetic biology platform for water quality monitoring - field testing and validation at the Camp Fire site in Paradise, California
GOALI: Advanced biomanufacturing with inducible feedback promoters
CAREER: Uncovering Quantitative Design Principles of RNA Regulators For Synthetic Biology
CAREER: Uncovering Quantitative Design Principles of RNA Regulators For Synthetic Biology
The Nuts and Bolts of Bioengineered Systems: A Workshop on Standards in Synthetic Biology; Valencia, Spain- March 8-10, 2015
Dynamic Control of Glycan Biosynthesis with Synthetic RNA Circuitry