Area of research
Molecular Biology · Surgery
Research interest
Research interests include CRISPR and Genetic Engineering, Single-cell and spatial transcriptomics, Genomics and Chromatin Dynamics, and Pluripotent Stem Cells Research.
MorPhiC Consortium: towards functional characterization of all human genes
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation