Erich Gulbins

Amitriptyline inhibits Plasmodium development in infected red blood cells by modulating sphingolipid metabolism and glucose uptake

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model

Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo

Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

Mitochondrial K+ channels and their implications for disease mechanisms

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

P. aeruginosa Induced Lipid Peroxidation Causes Ferroptotic Cell Death in Airways

Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Voltage-Gated Potassium Channels as Regulators of Cell Death

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation

<i>Pseudomonas aeruginosa</i> Pyocyanin Induces Neutrophil Death <i>via</i> Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase

Pharmacological targeting of ion channels for cancer therapy: In vivo evidences

Early effects of the antineoplastic agent salinomycin on mitochondrial function

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

Interclonal gradient of virulence in the <scp> <i>P</i> </scp> <i>seudomonas aeruginosa</i> pangenome from disease and environment

Mitochondrial ion channels as oncological targets

Targeting a mitochondrial potassium channel to fight cancer

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Impairs Lung Endothelial Cell Barrier Function and Increases Susceptibility to Microvascular Damage from Cigarette Smoke

Intracellular ion channels and cancer

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia