Area of research
Hepatology · Epidemiology
Research interest
Research interests include Liver Disease Diagnosis and Treatment, Drug Transport and Resistance Mechanisms, Liver physiology and pathology, and Drug-Induced Hepatotoxicity and Protection.
Enteronephrohepatic circulation of bile acids and therapeutic potential of systemic bile acid transporter inhibitors
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma
Sublethal necroptosis signaling promotes inflammation and liver cancer
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
Comparing in vitro human liver models to in vivo human liver using RNA-Seq
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Adverse outcome pathways: opportunities, limitations and open questions
The virtual liver: state of the art and future perspectives