Area of research
Pulmonary and Respiratory Medicine · Oncology
Research interest
Research interests include Cancer research, Biology, PTEN, Prostate cancer, Tumor microenvironment, and PI3K/AKT/mTOR pathway.
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer
PDX-derived organoids model in vivo drug response and secrete biomarkers
The Tug1 lncRNA locus is essential for male fertility
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis
Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
Vulnerabilities of <i>PTEN</i> – <i>TP53</i> -Deficient Prostate Cancers to Compound PARP–PI3K Inhibition
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer