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Sabina Signoretti

Cancer Research Center ·
Area of research
Pulmonary and Respiratory Medicine · Oncology
Research interest
Research interests include Renal cell carcinoma treatment, Cancer Immunotherapy and Biomarkers, Cancer Genomics and Diagnostics, and Bladder and Urothelial Cancer Treatments.
h-index
130
citations
97,428
works
1,151
NIH funding
primary concept
Medicine
email

Recent publications

A neoantigen vaccine generates antitumour immunity in renal cell carcinoma
Nature 2025cited by 153position: middledoi
Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma
Cancer Discovery 2025cited by 28position: middledoi
A Call for a Neoadjuvant Kidney Cancer Consortium: Lessons Learned from Other Cancer Types
European Urology 2025cited by 10position: middledoi
Contrastive learning enhances fairness in pathology artificial intelligence systems
Cell Reports Medicine 2025cited by 4position: middledoi
The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
Nature Communications 2025cited by 2position: middledoi
A pathology foundation model for cancer diagnosis and prognosis prediction
Nature 2024cited by 396position: middledoi
Perioperative nivolumab versus observation in patients with renal cell carcinoma undergoing nephrectomy (PROSPER ECOG-ACRIN EA8143): an open-label, randomised, phase 3 study
The Lancet Oncology 2024cited by 79position: middledoi
Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes
Cancer Cell 2024cited by 39position: middledoi
Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states
Cell Reports Medicine 2023cited by 37position: middledoi
Phase II study of nivolumab and salvage nivolumab/ipilimumab in treatment-naïve patients with advanced non-clear cell renal cell carcinoma (HCRN GU16-260-Cohort B)
Journal for ImmunoTherapy of Cancer 2023cited by 30position: middledoi
Pathological Outcomes of Patients With Advanced Renal Cell Carcinoma Who Receive Nephrectomy Following Immunotherapy
The Oncologist 2023cited by 19position: middledoi
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Cancer Cell 2022cited by 128position: middledoi
Obesity in Relation to Renal Cell Carcinoma Incidence and Survival in Three Prospective Studies
European Urology 2022cited by 31position: middledoi
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma
Cancer Cell 2021cited by 620position: middledoi
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma
Cancer Cell 2021cited by 505position: middledoi
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Nature Communications 2021cited by 163position: middledoi
A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes
Clinical Cancer Research 2021cited by 47position: middledoi
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
Nature Medicine 2020cited by 1,003position: middledoi
Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma
Clinical Cancer Research 2020cited by 234position: middledoi
Efficacy of Savolitinib vs Sunitinib in Patients With<i>MET</i>-Driven Papillary Renal Cell Carcinoma
JAMA Oncology 2020cited by 178position: middledoi
Phase II study of nivolumab and salvage nivolumab + ipilimumab in treatment-naïve patients (pts) with advanced renal cell carcinoma (RCC) (HCRN GU16-260).
Journal of Clinical Oncology 2020cited by 56position: middledoi
Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma
Journal for ImmunoTherapy of Cancer 2020cited by 36position: middledoi
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Nature Communications 2019cited by 858position: middledoi
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Science 2019cited by 433position: middledoi
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Science Signaling 2019cited by 85position: middledoi
The Future of Perioperative Therapy in Advanced Renal Cell Carcinoma: How Can We Prosper?
Future Oncology 2019cited by 42position: middledoi
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma
Science 2018cited by 1,286position: middledoi
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Cell Reports 2018cited by 800position: middledoi
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Cell Reports 2018cited by 775position: middledoi
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
Nature Genetics 2018cited by 693position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Toni K. Choueiri · Harvard University15 papers (2014–2024)William G. Kaelin · Harvard University9 papers (2013–2019)David F. McDermott · Dana-Farber/Harvard Cancer Center8 papers (2014–2023)Massimo Loda · Cornell University5 papers (2013–2014)Laurence Albigès · Institut Gustave Roussy5 papers (2014–2024)Jiaxi Song · Nanjing University of Chinese Medicine5 papers (2013–2017)Michael B. Atkins · Georgetown University4 papers (2014–2023)Lewis C. Cantley · Meyer (China)4 papers (2013–2014)Jesse Novak · Howard Hughes Medical Institute4 papers (2016–2018)Gordon J. Freeman · Harvard University4 papers (2014–2016)F. Stephen Hodi · Harvard University4 papers (2014–2016)Pier Paolo Pandolfi · The Ohio State University4 papers (2013–2018)John M. Asara · Harvard University4 papers (2013–2018)Abhishek A. Chakraborty · Case Western Reserve University4 papers (2016–2019)Naomi B. Haas · Samsung Medical Center4 papers (2017–2023)Catherine J. Wu · Dana-Farber/Harvard Cancer Center3 papers (2016–2023)Roderick T. Bronson · Tufts University3 papers (2014–2018)Rebecca B. Jennings · Stony Brook Medicine3 papers (2018–2019)Bradley A. McGregor · Harvard University3 papers (2017–2024) · 3 papers (2013–2018)