Area of research
Renewable Energy, Sustainability and the Environment · Molecular Biology
Research interest
Research interests include Metalloenzymes and iron-sulfur proteins, Metal-Catalyzed Oxygenation Mechanisms, RNA modifications and cancer, and CO2 Reduction Techniques and Catalysts.
Radical Fluoromethylation Enabled by Cobalamin-Dependent Radical SAM Enzymes
Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase
Structural basis for catalysis by human lipoyl synthase
Iron–sulfur cluster with double duty
In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA
Structural Evidence for DUF512 as a Radical <i>S</i>-Adenosylmethionine Cobalamin-Binding Domain
A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
Enzymatic Fluoromethylation Enabled by the <i>S</i>-Adenosylmethionine Analog <i>Te</i>-Adenosyl-<i>L</i>-(fluoromethyl)homotellurocysteine
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
How synonymous mutations alter enzyme structure and function over long timescales
Discovery, structure and mechanism of a tetraether lipid synthase
Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis
Twenty Years of Radical SAM! The Genesis of the Superfamily
[FeFe]‐Hydrogenase: Defined Lysate‐Free Maturation Reveals a Key Role for Lipoyl‐H‐Protein in DTMA Ligand Biosynthesis
In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1
Characterization of LipS1 and LipS2 from <i>Thermococcus kodakarensis</i>: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor
[FeFe]‐Hydrogenase: Defined Lysate‐Free Maturation Reveals a Key Role for Lipoyl‐H‐Protein in DTMA Ligand Biosynthesis
Structural characterization of cobalamin-dependent radical S-adenosylmethionine methylases
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB
First Step in Catalysis of the Radical <i>S</i>-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]<sup>0</sup>-Like Auxiliary Cluster
Radical S-Adenosylmethionine Methylases
Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin
Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical <i>S</i>-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System
Understanding the role of electron donors in the reaction catalyzed by Tsrm, a cobalamin-dependent radical S-adenosylmethionine methylase
An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase
The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes
Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical <i>S</i> -Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme
Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain
ASBMB Interactive Mentoring Activities for Grantsmanship Enhancement (IMAGE 2.0)
REU Site: Catalysis and Motion
Lipoic acid biosynthesis: understanding sulfur attachment to aliphatic carbon centers
REU Site: Catalysis and Motion
Interactive Mentoring Activities for Under-Represented Minority Faculty
Structure, Mechanism, and Regulation of Quinolinate Synthase, the First Committed Step in Bacterial NAD Biosynthesis
CONFERENCE: 2007 Enzymes, Co-Enzymes, and Metabolic Pathways Gordon Conference to be held in Biddeford, Maine on July 8-13, 2007
PECASE: Mechanistic Studies on Cyclopropane Fatty Acid Synthase