Area of research
Inorganic Chemistry · Molecular Biology
Research interest
Research interests include Metal-Catalyzed Oxygenation Mechanisms, Metalloenzymes and iron-sulfur proteins, Porphyrin Metabolism and Disorders, and Microbial metabolism and enzyme function.
Biochemical Studies of a Cyanobacterial Halogenase Support the Involvement of a Dimetal Cofactor
In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1
Characterization of LipS1 and LipS2 from <i>Thermococcus kodakarensis</i>: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB
First Step in Catalysis of the Radical <i>S</i>-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]<sup>0</sup>-Like Auxiliary Cluster
Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical <i>S</i> -Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme
Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical
Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase
Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from <i>Streptomyces fradiae</i>, a Cobalamin-Dependent Radical <i>S</i>-Adenosylmethionine Methylase
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
O–H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase
Spectroscopic and Electrochemical Characterization of the Iron–Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical <i>S</i>-Adenosylmethionine Methylase
Organometallic Complex Formed by an Unconventional Radical <i>S</i>-Adenosylmethionine Enzyme
Characterization of Lipoyl Synthase from <i>Mycobacterium tuberculosis</i>
Human calprotectin is an iron-sequestering host-defense protein
The COMBREX Project: Design, Methodology, and Initial Results
Function of the Diiron Cluster of<i>Escherichia coli</i>Class Ia Ribonucleotide Reductase in Proton-Coupled Electron Transfer
Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7-Deazapurines
Exploration of the chemical and mechanistic diversity of mixed-valent iron oxygenases and oxidases
Structures and Mechanisms of Two Enzymes that Produce Hydrocarbon Fuels from Abundant Metabolites
Conference: 4th Penn State Bioinorganic Workshop and the 4th "Frontiers in Metallobiochemistry" Symposium to be held at Penn State University; June 2 - June 10, 2016
Support for the 3rd Penn State Bioinorganic Workshop and the 3rd "Frontiers in Metallobiochemistry" Symposium, May 28 - June 4, 2014
Support for the 2nd Penn State Bioinorganic Workshop
Identification of the Dinuclear Metallo-Cofactor and Elucidation of the Reaction Mechanism of the Aldehyde Decarbonylase from the Alkane-producing Cyanobacterium Nostoc Punctiforme
Structure and function of intermediates involved in metalloenzymatic N-oygenation and oxidation reactions
Non-heme Fe(IV)-oxo Intermediates: Structure and Reactivity
An Integrative Approach to Metalloenzyme-Catalyzed C-H Activation