Area of research
Genetics · Molecular Biology
Research interest
Research interests include Genetic Associations and Epidemiology, Bioinformatics and Genomic Networks, Single-cell and spatial transcriptomics, and Genetic Mapping and Diversity in Plants and Animals.
Optimized summary-statistic-based single-cell eQTL meta-analysis
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
OTTERS: a powerful TWAS framework leveraging summary-level reference data
KidneyNetwork: using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Large-scale association analyses identify host factors influencing human gut microbiome composition
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Identification of context-dependent expression quantitative trait loci in whole blood
Biological interpretation of genome-wide association studies using predicted gene functions
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Gene expression analysis identifies global gene dosage sensitivity in cancer
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
Cell Specific eQTL Analysis without Sorting Cells
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci
Defining the role of common variation in the genomic and biological architecture of adult human height
Defining the role of common variation in the genomic and biological architecture of adult human height.
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia
Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians
Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands’