Area of research
Molecular Biology · Oncology
Research interest
Research interests include Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, DNA Repair Mechanisms, and Cancer-related Molecular Pathways.
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Discovery of a selective inhibitor of doublecortin like kinase 1
CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype
The dTAG system for immediate and target-specific protein degradation
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma