Area of research
Immunology · Molecular Biology
Research interest
Research interests include interferon and immune responses, Virus-based gene therapy research, Viral Infections and Vectors, and RNA regulation and disease.
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells.
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Epigenetic state determines the in vivo efficacy of STING agonist therapy
Innate Immune System Regulated by Stimulator of Interferon Genes, a Cytosolic DNA Sensor, Regulates Endothelial Function
STING Signaling Drives Production of Innate Cytokines, Generation of CD8+ T Cells and Enhanced Protection Against Trypanosoma cruzi Infection
Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma
STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection
Brucella suppress STING expression via miR-24 to enhance infection
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING
STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets
STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets.
STING signaling and host defense against microbial infection
STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function
<i>Brucella abortus</i> Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING
Epidemiology, clinical features, and outcome of HTLV-1–related ATLL in an area of prevalence in the United States
Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis
The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against <b><i>Mycobacterium tuberculosis</i></b> Infection
Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose
Cytoplasmic chromatin triggers inflammation in senescence and cancer
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis
Ubiquitination of STING at lysine 224 controls IRF3 activation
A noncanonical function of cGAMP in inflammasome priming and activation
The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation