Area of research
Molecular Biology · Epidemiology
Research interest
Research interests include Mitochondrial Function and Pathology, ATP Synthase and ATPases Research, Autophagy in Disease and Therapy, and Cell death mechanisms and regulation.
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis
Key challenges and recommendations for defining organelle membrane contact sites
Mitochondria–membranous organelle contacts at a glance
Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors
Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1
A guide to characterizing the dynamic mitochondria–endoplasmic reticulum contact sites
The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology
Glutamine sensing licenses cholesterol synthesis
Determinants and outcomes of mitochondrial dynamics
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Targeting mitochondrial shape: at the heart of cardioprotection
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation
High-Throughput Microscopy Analysis of Mitochondrial Membrane Potential in 2D and 3D Models
Dysfunctional mitochondria accumulate in a skeletal muscle knockout model of Smn1, the causal gene of spinal muscular atrophy
IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells
Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress
Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth
Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
OPA1 drives macrophage metabolism and functional commitment via p65 signaling
Transient Exposure of Endothelial Cells to Doxorubicin Leads to Long-Lasting Vascular Endothelial Growth Factor Receptor 2 Downregulation
Shaping fuel utilization by mitochondria
Autophagy in major human diseases
Dietary spermidine improves cognitive function
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites
A cross-sectional and prospective cohort study of the role of schools in the SARS-CoV-2 second wave in Italy
Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria
Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy