Area of research
Molecular Biology · Clinical Biochemistry
Research interest
Research focused on Mitochondrion and Cell biology, with related work in ATP synthase, mitochondrial fusion, Endoplasmic reticulum. Notable publications include 'Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency', 'The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage', and 'Determinants and outcomes of mitochondrial dynamics'.
Determinants and outcomes of mitochondrial dynamics
Dysfunctional mitochondria accumulate in a skeletal muscle knockout model of Smn1, the causal gene of spinal muscular atrophy
Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
Who and how in the regulation of mitochondrial cristae shape and function
(Neuro)degenerated Mitochondria-ER contacts
The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
Early effects of the antineoplastic agent salinomycin on mitochondrial function
Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency