Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Cancer Genomics and Diagnostics, Acute Myeloid Leukemia Research, CRISPR and Genetic Engineering, and Lung Cancer Treatments and Mutations.
Next-generation characterization of the Cancer Cell Line Encyclopedia
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Defining a Cancer Dependency Map
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
Characterizing genomic alterations in cancer by complementary functional associations
The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Absolute quantification of somatic DNA alterations in human cancer
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
Cancer Vulnerabilities Unveiled by Genomic Loss
Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene <i>ID4</i>