Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Biology, Cancer research, Gene, Computational biology, Cancer, and CRISPR.
Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for <i>CSNK1A1</i> in clonal expansion
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Defining a Cancer Dependency Map
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase
HIF activation causes synthetic lethality between the <i>VHL</i> tumor suppressor and the <i>EZH1</i> histone methyltransferase
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models
<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML
Integrated genetic and pharmacologic interrogation of rare cancers
Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
In vivo discovery of immunotherapy targets in the tumour microenvironment
The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection
( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Cancer Vulnerabilities Unveiled by Genomic Loss