Christopher T. Pappas

Lmod2 is necessary for effective skeletal muscle contraction

Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant

In vivo elongation of thin filaments results in heart failure

Disruption of cardiac thin filament assembly arising from a mutation in <i>LMOD2</i> : A novel mechanism of neonatal dilated cardiomyopathy

Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure

Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

HSPB7 is indispensable for heart development by modulating actin filament assembly

Mutation‐specific effects on thin filament length in thin filament myopathy

Nebulin, a multi-functional giant

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2’s function

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function