Area of research
Genetics · Surgery
Research interest
Research interests include Genetic Associations and Epidemiology, Lipoproteins and Cardiovascular Health, Genomics and Rare Diseases, and BRCA gene mutations in cancer.
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Covering medical care costs for participants in the eMERGE Network: Challenges for equity and implementation
Abstract 4369684: Mitochondrial DNA Copy Number (mtDNA-CN): Associations with Mortality and Gene Expression in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Biorepository
Abstract 4366483: Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Atrial Fibrillation and Clonal Hematopoiesis in <i>TET2</i> and <i>ASXL1</i>
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization
Abstract 4124065: Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Chronic Coronary Artery Disease: A Report from the ISCHEMIA Trials Biorepository
Principles and methods for transferring polygenic risk scores across global populations
Returning integrated genomic risk and clinical recommendations: The eMERGE study
Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization
Risk factors affecting polygenic score performance across diverse cohorts
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Polygenic scores in biomedical research
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Improving reporting standards for polygenic scores in risk prediction studies
Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
Clinical Applications Measuring Arterial Stiffness: An Expert Consensus for the Application of Cardio-Ankle Vascular Index
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts
Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids