Yong‐Mi Kim

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation

The Wnt signaling pathway in cancer

Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

Gang EJ, Hsieh YT, Pham J, Zhao Yi, Nguyen Cu, Huantes S, Park E, Naing K, Klemm L, Swaminathan S, Conway EM, Pelus L, Crispino J, Mullighan C, MacMillan M, Müschen M, Kahn M, Kim YM . Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leuke

Hsieh YT, Gang EJ, Shishido S, Kim HN,  Pham J, Khazal S, Osborne A, Esguerra ZA, Kwon E, Jang J, Bonig H, Biediger RJ, Vanderslice P, Kim YM . Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells. Leukemia , 2014; 28(10):2101-4.

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

Hsieh YT*, Gang EJ*, Geng HM, Park E*, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, , Shimada H, Shojaee S, Parameswaran R, Klemm L, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H,  Kim YM . Integrin alpha4 block

The bone marrow niche has been found to be chemoprotective for leukemia cells, contributing to the lack of efficacy of treatment. Thus, dislodging leukemia cells from their protective niche by breaking adhesive bonds (anoikis) may make drug treatment more effective. We have identified integrin alpha

Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh  M, Conway EM, Kang ES, Koo HH, Hofmann WK, Heisterkamp N, Pelus L, Keerthivasan G, Crispino J, Kahn M, Müschen M and  Kim, YM . Targeting Survivin Overcomes Drug Resistance in Acute Lymphoblastic Leukemia.  Blood , 2011, 118(8),

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