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Peter St George‐Hyslop

University Health Network ·
Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Cholinesterase and Neurodegenerative Diseases, and Bioinformatics and Genomic Networks.
h-index
121
citations
81,064
works
689
NIH funding
primary concept
email

Recent publications

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Nature Communications 2025cited by 13position: lastdoi
CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer’s Disease Susceptibility
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 2position: middledoi
Sialylated Clusterin Binds CD33 to Regulate Microglial Functions in Alzheimer's Disease
Alzheimer s & Dementia 2025cited by 1position: lastdoi
The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact
Alzheimer s & Dementia 2024cited by 80position: middledoi
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease
JAMA Neurology 2024cited by 27position: middledoi
Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
Alzheimer s & Dementia 2024cited by 20position: middledoi
X‐chromosome-wide association study for Alzheimer’s disease
Molecular Psychiatry 2024cited by 6position: middledoi
Novel Stop-gain SORL1 Mutation in a Peruvian Family with Alzheimer’s Disease of the PeADI Study (P6-9.017)
Neurology 2024cited by 5position: middledoi
The liquid-to-solid transition of FUS is promoted by the condensate surface
Proceedings of the National Academy of Sciences 2023cited by 179position: middledoi
Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood
Biological Psychiatry 2022cited by 49position: middledoi
Z-α <sub>1</sub> -antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state
Science Advances 2022cited by 43position: middledoi
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Nature Genetics 2021cited by 475position: middledoi
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Communications Biology 2020cited by 102position: middledoi
Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies
Acta Neuropathologica Communications 2020cited by 42position: middledoi
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
Scientific Reports 2020cited by 10position: middledoi
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Brain 2019cited by 239position: middledoi
TET2 Regulates the Neuroinflammatory Response in Microglia
Cell Reports 2019cited by 101position: middledoi
Heritability and genetic variance of dementia with Lewy bodies
Neurobiology of Disease 2019cited by 44position: middledoi
Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia
Scientific Reports 2019cited by 16position: middledoi
Analysis of shared heritability in common disorders of the brain
Science 2018cited by 2,016position: middledoi
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
Cell 2018cited by 930position: lastdoi
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Nature Medicine 2018cited by 155position: middledoi
CXCR4 involvement in neurodegenerative diseases
Translational Psychiatry 2018cited by 98position: middledoi
Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS
Scientific Reports 2018cited by 2position: middledoi
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
The Lancet Neurology 2017cited by 286position: middledoi
TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant
EMBO Molecular Medicine 2017cited by 222position: middledoi
Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
Alzheimer s & Dementia 2017cited by 210position: middledoi
Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS
Scientific Reports 2017cited by 44position: middledoi
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Alzheimer s & Dementia 2016cited by 94position: middledoi
<i>SORL1</i> mutations in early- and late-onset Alzheimer disease
Neurology Genetics 2016cited by 86position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Lindsay A. Farrer · Boston University6 papers (2012–2018)Badri N. Vardarajan · University of Southern California5 papers (2012–2025)Ekaterina Rogaeva · University of Toronto5 papers (2012–2015) · 5 papers (2013–2023)Margaret A. Pericak‐Vance · University of Miami4 papers (2013–2024)Richard Mayeux · Global Brain Health Institute4 papers (2012–2016)Paul E. Fraser · Ontario Institute for Cancer Research4 papers (2012–2018)David Klenerman · UK Dementia Research Institute4 papers (2013–2020) · 3 papers (2013–2025)Sam Gandy · James J. Peters VA Medical Center3 papers (2012–2014)Christopher Böhm · University Health Network3 papers (2013–2025)Patrick R. Hof · Allen Institute for Brain Science2 papers (2012–2014)Hannah Brautigam · University of Wisconsin–Madison2 papers (2012–2014)Priyanka Narayan · National Institutes of Health2 papers (2013–2014)Christopher M. Dobson · University of Cambridge2 papers (2013–2014) · 2 papers (2025–2025)Jean‐Charles Lambert · Inserm2 papers (2012–2012)Giuseppe Tosto · NewYork–Presbyterian Hospital2 papers (2013–2015)Clemens F. Kaminski · Cancer Research UK Cambridge Center2 papers (2018–2022)Gerold Schmitt‐Ulms · University of Toronto2 papers (2013–2018)