Area of research
Neurology · Molecular Biology
Research interest
Research interests include Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, Genetic Neurodegenerative Diseases, and RNA Research and Splicing.
Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia
Stress granule formation helps to mitigate neurodegeneration
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration
TorsinA is essential for neuronal nuclear pore complex localization and maturation
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology
TDP-43 stabilizes <i>G3BP1</i> mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models