Area of research
Neurology · Cell Biology
Research interest
Research interests include Thioredoxin, Cytosol, Biology, Clostridium botulinum, Biochemistry, and Botulism.
The complex web of membrane contact sites in brain aging and neurodegeneration
Selective endocytosis of Ca <sup>2+</sup> -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
The axonal endolysosomal and autophagic systems
Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip
Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals
The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals
On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments
Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism
The thioredoxin reductase – Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles
Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins