Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Single-cell and spatial transcriptomics, Occupational and environmental lung diseases, Cancer Genomics and Diagnostics, and Immune cells in cancer.
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations
Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines
NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma
Expanding GABAergic Neuronal Diversity in PSC-Derived Disease Models
An integrated cell atlas of the lung in health and disease
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression
Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma
A cellular and spatial atlas of <i>TP53</i> -associated tissue remodeling in lung adenocarcinoma
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation
A comparison of non-integrating reprogramming methods
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Genome-wide identification and characterization of replication origins by deep sequencing