Area of research
Sensory Systems · Molecular Biology
Research interest
Research focused on Hearing loss and Adverse effect, with related work in Cell biology, Genome editing, Transfection. Notable publications include 'Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo', 'Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents', and 'AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial'.
Viral and non-viral vectors in gene therapy: current state and clinical perspectives
Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9
Audiological characteristics following gene therapy in patients with autosomal recessive deafness 9
PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation
Treating Hearing Loss: From Cochlear Implantation to Gene Therapy
Clinical gene therapy restores hearing: a paradigm shift
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials
Comparative analysis of RNA versus protein splicing in dual AAV-mediated gene therapy in a mouse model of DFNB9 deafness
P3.12.31 Rezivertinib in Advanced NSCLC Patients With EGFR T790M Mutation via Tissue/Plasma Samples: Pooled Analysis of 2 Clinical Studies
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness
Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation
Advances in gene therapy hold promise for treating hereditary hearing loss
Nanobiomaterial vectors for improving gene editing and gene therapy
Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo
RNA base editing therapy cures hearing loss induced by OTOF gene mutation
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates
The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss
Microfluidic Preparation of Gelatin Methacryloyl Microgels as Local Drug Delivery Vehicles for Hearing Loss Therapy
Approaches and Vectors for Efficient Cochlear Gene Transfer in Adult Mouse Models
Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice
A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel <scp>KCNQ4</scp> mutation (p. <scp>G228D</scp> ) from a large Chinese family