Area of research
Sensory Systems · Molecular Biology
Research interest
Research interests include Hearing, Cochlea, Tinnitus, Genetics, Hearing Loss and Rehabilitation, RNA regulation and disease, and CRISPR and Genetic Engineering.
Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9
Clinical gene therapy restores hearing: a paradigm shift
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates
The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice
Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss
Two-dimensional Ti3C2Tx MXene promotes electrophysiological maturation of neural circuits
Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice
A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel <scp>KCNQ4</scp> mutation (p. <scp>G228D</scp> ) from a large Chinese family
Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea
Gene editing in a Myo6 semi-dominant mouse model rescues auditory function
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing
AAV-ie enables safe and efficient gene transfer to inner ear cells
Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea
A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern
Autophagy protects auditory hair cells against neomycin-induced damage
Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by <i>In Vivo</i> Genetic Reprogramming in the Neonatal Mouse Cochlea
Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways
Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation