Area of research
Sensory Systems · Neurology
Research interest
Research interests include Biology, Cell biology, Cochlea, Wnt signaling pathway, Hair cell, and Progenitor cell.
PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results
P2X7 receptor is required for the ototoxicity caused by aminoglycoside in developing cochlear hair cells
Generation of innervated cochlear organoid recapitulates early development of auditory unit
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing
The crosstalk between the Notch, Wnt, and SHH signaling pathways in regulating the proliferation and regeneration of sensory progenitor cells in the mouse cochlea
Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea
Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea
A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern
Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea
Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle
Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea
Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea
Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by <i>In Vivo</i> Genetic Reprogramming in the Neonatal Mouse Cochlea
Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea
Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment
Genetic testing for sporadic hearing loss using targeted massively parallel sequencing identifies 10 novel mutations
Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity
SASH1 regulates melanocyte transepithelial migration through a novel Gαs–SASH1–IQGAP1–E-Cadherin dependent pathway