Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Serine and Library science, with related work in Translational frameshift, Translation (biology), Enhancer. Notable publications include 'eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription', 'Anti-tumour immunity induces aberrant peptide presentation in melanoma', and 'Tryptophan depletion results in tryptophan-to-phenylalanine substitutants'.
Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
DNA damage induces p53-independent apoptosis through ribosome stalling
Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
Gene and protein sequence features augment HLA class I ligand predictions
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers
Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
Oncogene-dependent sloppiness in mRNA translation
A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
SLC1A3 contributes to L‐asparaginase resistance in solid tumors
A fragment-like approach to PYCR1 inhibition
Micro-RNA 124 Regulates Homologous Recombination Protein RAD51 and Sensitizes Glioblastoma Cells to Radiation
Long non-coding RNAs in metastasis
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription