Area of research
Molecular Biology
Research interest
Research interests include Genomics and Chromatin Dynamics, RNA Research and Splicing, Epigenetics and DNA Methylation, and RNA and protein synthesis mechanisms.
GREGoR: accelerating genomics for rare diseases
Single-cell genomics and regulatory networks for 388 human brains
Deciphering the impact of genomic variation on function
Multicenter integrated analysis of noncoding CRISPRi screens
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Single-cell genomics and regulatory networks for 388 human brains
Integrating gene annotation with orthology inference at scale
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Three-dimensional genome rewiring in loci with human accelerated regions
The contribution of historical processes to contemporary extinction risk in placental mammals
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
The functional and evolutionary impacts of human-specific deletions in conserved elements
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
Evolution of the ancestral mammalian karyotype and syntenic regions
Annotation of chromatin states in 66 complete mouse epigenomes during development
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Comprehensive functional genomic resource and integrative model for the human brain
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice