Area of research
Molecular Biology · Genetics
Research interest
Research interests include CRISPR and Genetic Engineering, Pluripotent Stem Cells Research, RNA regulation and disease, and RNA and protein synthesis mechanisms.
Mushroom Derived STS-HMGS Fusion Enzyme Enhances Sesquiterpene Production in Fungal Hosts
A Comprehensive Study of AAV Tropism in the Marmoset Brain.
Cas13-Mediated RNA Base Editing for the Treatment of Hereditary Hypertrophic Cardiomyopathy.
Engineered IscB-ωRNA system with expanded target range for base editing.
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates.
Tuber indicum colonization enhances plant drought tolerance by modifying physiological, rhizosphere metabolic and bacterial community responses in Pinus armandii
Bispectral Index–guided Anesthesia for Older Patients Having Noncardiac Surgery: A Randomized Multicenter Trial
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model
Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase.
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model.
Therapeutic effect of nicotinamide mononucleotide on Alzheimer’s disease through activating autophagy and anti-oxidative stress
Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model.
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase.
Development of miniature base editors using engineered IscB nickase.
Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing.
Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase.
RNA base editing therapy cures hearing loss induced by OTOF gene mutation
RNA base editing therapy cures hearing loss induced by OTOF gene mutation.
A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice.
An engineered xCas12i with high activity, high specificity, and broad PAM range.
Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo.
A novel soybean malectin-like receptor kinase-encoding gene, <i>GmMLRK1,</i> provides resistance to soybean mosaic virus
Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e.
Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice.
In vivo treatment of tyrosinaemia with hypercompact Cas12f1.
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor.
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor.
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos.
Collaborative Research: Human-centered AI for Reconfigurable Manufacturing Operation and desigN sYnthesis (HARMONY)
Collaborative Research: III: Small: A DREAM Proactive Conversational System
I-Corps: Translation potential of using artificial intelligence (AI) to diagnose Alzheimer’s disease and other dementia-related disorders
Collaborative Research: An Extended Reality Factory Innovation for Adaptive Problem-solving and Personalized Learning in Manufacturing Engineering
I-Corps: Additive Manufacturing Quality Control Software
RAPID: Developing Advanced Modeling and Analysis Tools to track Human Movement Patterns and Coronavirus / Infectious Disease Spread Dynamics in Geographical Networks
Collaborative Research: Data-driven integration of biological with in-silico experiments to determine mechanistic effects of N-glycosylation on cellular electromechanical functions
Phase II I/UCRC Pennsylvania State University Site: Center for Health Organization Transformation
EAGER/Collaborative Research: Sensing, Modeling and Optimization of Postoperative Heart Health Management
III: Student Travel Fellowships for SIGIR Privacy-Preserving IR Workshop 2016
Collaborative Research: Travel Support for Students to Attend the 2016 Industrial and Systems Engineering Research Conference (ISERC); Anaheim, California; May 21-24, 2016
CAREER: Statistical Information Retrieval Modeling for Complex Search
CAREER: Sensor-based Modeling and Control of Nonlinear Dynamics in Complex Systems for Quality Improvements in Manufacturing and Healthcare
CAREER: Sensor-based Modeling and Control of Nonlinear Dynamics in Complex Systems for Quality Improvements in Manufacturing and Healthcare
Collaborative Research: Physical-Statistical Modeling and Optimization of Cardiovascular System
I-Corps: Mobile and E-network Smart Health (MESH)
Collaborative Research: Physical-Statistical Modeling and Optimization of Cardiovascular System