Area of research
Molecular Biology · Plant Science
Research interest
Research interests include CRISPR and Genetic Engineering, Soybean genetics and cultivation, Gut microbiota and health, and RNA regulation and disease.
Cas13-Mediated RNA Base Editing for the Treatment of Hereditary Hypertrophic Cardiomyopathy.
A comprehensive study of AAV tropism across C57BL/6 mice, BALB/c mice, and crab-eating macaques
Characterization of Main Responsive Genes Reveals Their Regulatory Network Attended by Multi-Biological Metabolic Pathways in Paclobutrazol (PAC)-Modulated Grape Seed Development (GSD) at the Stone-Hardening Stage
Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a
Programmable G-to-Y base editing using engineered DNA glycosylase.
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase.
Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing.
Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase.
A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice.
An engineered xCas12i with high activity, high specificity, and broad PAM range.
Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo.
Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e.
Limitations of gene editing assessments in human preimplantation embryos.
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor.
A functionally divergent SOC1 homolog improves soybean yield and latitudinal adaptation
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor.
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos.
Gene editing in a Myo6 semi-dominant mouse model rescues auditory function.
Downregulation of a gibberellin 3β‐hydroxylase enhances photosynthesis and increases seed yield in soybean
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE.
Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice
Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice.
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration.
Ectopic expression of GmRNF1a encoding a soybean E3 ubiquitin ligase affects Arabidopsis silique development and dehiscence
Author Correction: Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes.
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo
Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes.