Area of research
Molecular Biology
Research interest
Research interests include CRISPR and Genetic Engineering, Pluripotent Stem Cells Research, RNA regulation and disease, and RNA and protein synthesis mechanisms.
Engineered IscB-ωRNA system with expanded target range for base editing.
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates.
Development and validation of an MPS-based 513-Plex SNP identity panel for degraded forensic samples
Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model.
Body fluids should be identified before estimating the time since deposition (TsD) in microbiome-based stain analyses for forensics
Development of miniature base editors using engineered IscB nickase.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
RNA base editing therapy cures hearing loss induced by OTOF gene mutation
Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.
The Effects of Drug Addiction and Detoxification on the Human Oral Microbiota
Tracing recent outdoor geolocation by analyzing microbiota from shoe soles and shoeprints even after indoor walking
Predicting the postmortem interval of burial cadavers based on microbial community succession
Precise genome editing without exogenous donor DNA via retron editing system in human cells.
Development and validation of a multiplex 19 X-chromosomal short tandem repeats typing system for forensic purposes
Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs.
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners.
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration.
Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice.
DNA typing from skeletal remains: a comparison between capillary electrophoresis and massively parallel sequencing platforms
Screened AAV variants permit efficient transduction access to supporting cells and hair cells.
Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
CRISPR/Cas9-mediated targeted chromosome elimination
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency
The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
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