Area of research
Biochemistry · Physiology
Research interest
Research focused on Endoplasmic reticulum and Cell biology, with related work in PDK4, Metabolomics, Metastasis. Notable publications include 'Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression', 'Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans', and 'Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats'.
Protection against ferroptosis through maintaining homeostasis of docosahexaenoate-containing phospholipids
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER
LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience
Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats
Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression
Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans